Synthetic Studies toward (±)-Furanocembranoid 1: Construction of the Acyclic Carbon Framework.

ABSTRACT: Herein, we report the synthesis of the entire acyclic carbon framework toward (±)-furanocembranoid 1 via the longest linear sequence of 12 steps from commercially available linalool and diethyl 2-isopropylmalonate. Key to the success of this synthetic approach is a silver-catalyzed enyne-annulation reaction for the formation of 2,4-disubstituted furan motif of unique furanocembranoid 1, isolated from Croton oblongifolius. Construction of macrocycle has also been explored using the ring-closing metathesis reaction.

SUBMITTER: Raji Reddy C 

PROVIDER: S-EPMC6644170 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature