The Inflammasome Adaptor ASC Intrinsically Limits CD4⁺ T-Cell Proliferation to Help Maintain Intestinal Homeostasis.

ABSTRACT: The inflammasome is a multi-protein complex that mediates proteolytic cleavage and release of the pro-inflammatory cytokines IL-1β and IL-18, and pyroptosis-a form of cell death induced by various pathogenic bacteria. Apoptosis-associated speck-like protein containing a CARD (ASC) has a pivotal role in inflammasome assembly and activation. While ASC function has been primarily implicated in innate immune cells, its contribution to lymphocyte biology is unclear. Here we report that ASC is constitutively expressed in naïve CD4⁺ T cells together with the inflammasome sensor NLRP3 and caspase-1. When adoptively transferred in immunocompromised Rag1^-/- mice, Asc^-/- CD4⁺ T cells exacerbate T-cell-mediated autoimmune colitis. Asc^-/- CD4⁺

SUBMITTER: Javanmard Khameneh H 

PROVIDER: S-EPMC6644529 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature