Androgen treatment effects on hippocampus structure in boys with Klinefelter syndrome.

ABSTRACT: Klinefelter syndrome (KS, 47,XXY) is the most common sex chromosome aneuploidy in males. A variety of complex clinical needs is associated with KS, including physical, cognitive and psychosocial impairments. Standard treatment for KS consists of androgen replacement therapy in adolescence to offset testosterone deficiency. Such treatment has a beneficial effect on the physical and behavioral manifestations of this syndrome. Whether androgen supplementation has a significant influence on the brain, however, is unknown. In the current study, we examined regional gray matter volume in boys with KS to assess whether treatment with oxandrolone, a synthetic hormone analog of testosterone, was associated with structural changes in the brain. Specifically, we focused our investigation on the hippo

SUBMITTER: Foland-Ross LC 

PROVIDER: S-EPMC6644684 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature