Maternal inflammation during pregnancy and offspring psychiatric symptoms in childhood: Timing and sex matter.

ABSTRACT:

Objective

Maternal infection during pregnancy has been associated with increased risk of offspring psychopathology, including depression. As most infections do not cross the placenta, maternal immune responses to infection have been considered as potentially contributing to this relationship. This study examined whether gestational timing of maternal inflammation during pregnancy is associated with offspring internalizing and/or externalizing symptoms during childhood and, further, whether fetal sex moderated this relationship.

Method

Participants were 737 pregnant women and their offspring who were continuously followed through late childhood. Archived first and second trimester sera were analyzed for markers of inflammation [interleukin 8 (IL-8), IL-6, IL-1 receptor antago

SUBMITTER: Mac Giollabhui N 

PROVIDER: S-EPMC6644717 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature