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Colorimetric Calcium Probe with Comparison to an Ion-Selective Optode.

ABSTRACT: Design strategies for small molecular probes lay the foundation of numerous synthetic chemosensors. A water-soluble colorimetric calcium molecular probe inspired by the ionophore-based ion-selective optode is presented here with a tunable detection range (around micromolar at pH 7). The binding of Ca²⁺ resulted in the deprotonation of the probe and thus a significant spectral change, mimicking the ion-exchange process in ion-selective optodes. The 1:1 exchange between Ca²⁺ and H⁺ was confirmed with Job's plot. Computational studies revealed possible monomer and dimer forms of the probe-Ca²⁺ complexes.

SUBMITTER: Zhu C

PROVIDER: S-EPMC6644788 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Colorimetric Calcium Probe with Comparison to an Ion-Selective Optode.

Zhu Changyou C Huang Manling M Lan Jialing J Chung Lung Wa LW Li Xin X Xie Xiaojiang X

ACS omega 20181003 10

Design strategies for small molecular probes lay the foundation of numerous synthetic chemosensors. A water-soluble colorimetric calcium molecular probe inspired by the ionophore-based ion-selective optode is presented here with a tunable detection range (around micromolar at pH 7). The binding of Ca2+ resulted in the deprotonation of the probe and thus a significant spectral change, mimicking the ion-exchange process in ion-selective optodes. The 1:1 exchange between Ca2+ ...[more]

PMID: 31457978

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