Maturation of the Human Cerebral Cortex During Adolescence: Myelin or Dendritic Arbor?

ABSTRACT: Previous in vivo studies revealed robust age-related variations in structural properties of the human cerebral cortex during adolescence. Neurobiology underlying these maturational phenomena is largely unknown. Here we employ a virtual-histology approach to gain insights into processes associated with inter-regional variations in cortical microstructure and its maturation, as indexed by magnetization transfer ratio (MTR). Inter-regional variations in MTR correlate with inter-regional variations in expression of genes specific to pyramidal cells (CA1) and ependymal cells; enrichment analyses indicate involvement of these genes in dendritic growth. On the other hand, inter-regional variations in the change of MTR during adolescence correlate with inter-regional profiles of oligodendrocyte-sp

SUBMITTER: Patel Y 

PROVIDER: S-EPMC6644857 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature