Ontology highlight
ABSTRACT:
SUBMITTER: Skowron KJ
PROVIDER: S-EPMC6645384 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Molecular and cellular endocrinology 20190601
The purpose of this review is to highlight recent developments in small molecules and peptides that block the binding of coactivators to steroid receptors. These coactivator binding inhibitors bind at the coregulator binding groove, also known as Activation Function-2, rather than at the ligand-binding site of steroid receptors. Steroid receptors that have been targeted with coactivator binding inhibitors include the androgen receptor, estrogen receptor and progesterone receptor. Coactivator bin ...[more]