High-Throughput Aqueous Two-Phase System Droplet Generation by Oil-Free Passive Microfluidics.

ABSTRACT: Aqueous two-phase system (ATPS) droplet generation has significant potential in biological and medical applications because of its excellent biocompatibility. However, the ultralow interfacial tension of ATPS makes droplet generation extremely challenging when compared with the conventional water-in-oil (W/O) system. In this paper, we passively produced ATPS droplets with a wide range of droplet size and high production rate without the involvement of an oil phase and external forces. For the first time, we reported important information of the flow rate and capillary (Ca) number for passive, oil-free ATPS droplet generation. It was found that the range of Ca numbers of the continuous phase under the jetting flow regime is 0.3-1.7, as compared to less than 0.1 in the W/O syst

SUBMITTER: Mastiani M 

PROVIDER: S-EPMC6645416 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature