Preservation of cellular nano-architecture by the process of chemical fixation for nanopathology.

ABSTRACT: Transformation in chromatin organization is one of the most universal markers of carcinogenesis. Microscale chromatin alterations have been a staple of histopathological diagnosis of neoplasia, and nanoscale alterations have emerged as a promising marker for cancer prognostication and the detection of predysplastic changes. While numerous methods have been developed to detect these alterations, most methods for sample preparation remain largely validated via conventional microscopy and have not been examined with nanoscale sensitive imaging techniques. For these nanoscale sensitive techniques to become standard of care screening tools, new histological protocols must be developed that preserve nanoscale information. Partial Wave Spectroscopic (PWS) microscopy has recently emerged as a nove

SUBMITTER: Zhou X 

PROVIDER: S-EPMC6645510 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature