Deficiency of Adipocyte IKKβ Affects Atherosclerotic Plaque Vulnerability in Obese LDLR Deficient Mice.

ABSTRACT: Background Obesity-associated chronic inflammation has been known to contribute to atherosclerosis development, but the underlying mechanisms remain elusive. Recent studies have revealed novel functions of IKK β (inhibitor of NF -κB [nuclear factor κB] kinase β), a key coordinator of inflammation through activation of NF -κB, in atherosclerosis and adipose tissue development. However, it is not clear whether IKK β signaling in adipocytes can also affect atherogenesis. This study aims to investigate the impact of adipocyte IKK β expression on atherosclerosis development in lean and obese LDLR (low-density lipoprotein receptor)-deficient ( LDLR ^-/-) mice. Methods and Results To define the role of adipocyte IKK β in atherogenesis, we generated adipocyte-specific IKK β-deficient LDL

SUBMITTER: Lu W 

PROVIDER: S-EPMC6645619 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature