Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload.

ABSTRACT:

Rationale

The Hippo pathway plays an important role in determining organ size through regulation of cell proliferation and apoptosis. Hippo inactivation and consequent activation of YAP (Yes-associated protein), a transcription cofactor, have been proposed as a strategy to promote myocardial regeneration after myocardial infarction. However, the long-term effects of Hippo deficiency on cardiac function under stress remain unknown.

Objective

We investigated the long-term effect of Hippo deficiency on cardiac function in the presence of pressure overload (PO).

Methods and results

We used mice with cardiac-specific homozygous knockout of WW45 (WW45cKO), in which activation of Mst1 (Mammalian sterile 20-like 1) and Lats2 (large tumor suppressor kinase 2), the upstream kin

SUBMITTER: Ikeda S 

PROVIDER: S-EPMC6645688 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature