Determining Possible Shared Genetic Architecture Between Myopia and Primary Open-Angle Glaucoma.

ABSTRACT:

Purpose

To determine genetic correlations between common myopia and primary open-angle glaucoma (POAG).

Methods

We tested the association of myopia polygenic risk scores (PRSs) with POAG and POAG endophenotypes using two studies: the Australian & New Zealand Registry of Advanced Glaucoma (ANZRAG) study comprising 798 POAG cases with 1992 controls, and the Rotterdam Study (RS), a population-based study with 11,097 participants, in which intraocular pressure (IOP) and optic disc parameter measurements were catalogued. PRSs were derived from genome-wide association study meta-analyses conducted by the Consortium for Refractive Error and Myopia (CREAM) and 23andMe. In total, 12 PRSs were constructed and tested. Further, we explored the genetic correlation between myopia, POAG, a

SUBMITTER: Iglesias AI 

PROVIDER: S-EPMC6645704 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature