Arginine and Carnitine Metabolites Are Altered in Diabetic Retinopathy.

ABSTRACT:

Purpose

To determine plasma metabolite and metabolic pathway differences between patients with type 2 diabetes with diabetic retinopathy (DR) and without retinopathy (diabetic controls), and between patients with proliferative DR (PDR) and nonproliferative DR (NPDR).

Methods

Using high-resolution mass spectrometry with liquid chromatography, untargeted metabolomics was performed on plasma samples from 83 DR patients and 90 diabetic controls. Discriminatory metabolic features were identified through partial least squares discriminant analysis, and linear regression was used to adjust for age, sex, diabetes duration, and hemoglobin A1c. Pathway analysis was performed using Mummichog 2.0.

Results

In the adjusted analysis, 126 metabolic features differed significantly bet

SUBMITTER: Sumarriva K 

PROVIDER: S-EPMC6645705 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature