Characterization of synovial fluid metabolomic phenotypes of cartilage morphological changes associated with osteoarthritis.

ABSTRACT:

Objective

Osteoarthritis (OA) is a multifactorial disease with etiological heterogeneity. The objective of this study was to classify OA subgroups by generating metabolomic phenotypes from human synovial fluid.

Design

Post mortem synovial fluids (n = 75) were analyzed by high performance-liquid chromatography mass spectrometry (LC-MS) to measure changes in the global metabolome. Comparisons of healthy (grade 0), early OA (grades I-II), and late OA (grades III-IV) donor populations were considered to reveal phenotypes throughout disease progression.

Results

Global metabolomic profiles in synovial fluid were distinct between healthy, early OA, and late OA donors. Pathways differentially activated among these groups included structural deterioration, glycerophospholipid

SUBMITTER: Carlson AK 

PROVIDER: S-EPMC6646055 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature