Unknown

Dataset Information

0

Cis-regulatory genetic variants in the CCR5 gene and natural HIV-1 control in black South Africans.


ABSTRACT: Studies have investigated CCR5 haplotypes (HHA, HHB, HHC, HHD, HHE, HHF*1, HHF*2, HHG*1, HHG*2), defined by seven 5'UTR single nucleotide polymorphisms (SNPs), CCR2-V64I and CCR5?32, in HIV-1 disease. CCR5 cis-regulatory regions were sequenced, CCR2-V64I and CCR5?32 genotyped, and compared in HIV-1-infected black South Africans: 71 HIV-1 controllers (23 elite controllers, 37 viraemic controllers (VCs), 11 high viral load long-term non-progressors) and 74 progressors. The HHE haplotype and 3'UTR +2919?T?>?G SNP heterozygosity were underrepresented in total controllers and VCs vs. progressors (p?=?.004; p?=?.007 and p?=?.002, pbonferroni?=?0.032; p?=?.004, respectively). Possession of the +2919?T?>?G SNP (dominant mode) was associated with HIV-1 progression (controllers vs. progressors: p?=?.001, pbonferroni?=?0.016). The +2919?T?>?G SNP is in linkage disequilibrium (LD; r2?=?0.73) with two 5'UTR SNPs (-2459G?>?A and -2135?T?>?C; r2?=?1: 5'UTR-2SNP-hap). The 5'UTR-2SNP-hap was lower in total controllers and VCs vs. progressors (p?=?.003, pbonferroni?=?0.048; p?=?.01, respectively). Results suggest -2459G?>?A, -2135?T?>?C, and?+?2919?T?>?G as key CCR5 variants in HIV-1 control.

SUBMITTER: Koor GW 

PROVIDER: S-EPMC6646080 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

Cis-regulatory genetic variants in the CCR5 gene and natural HIV-1 control in black South Africans.

Koor Gemma W GW   Paximadis Maria M   Picton Anabela C P ACP   Karatas Fidan F   Loubser Shayne A SA   He Weijing W   Ahuja Sunil K SK   Chaisson Richard E RE   Martinson Neil N   Ebrahim Osman O   Tiemessen Caroline T CT  

Clinical immunology (Orlando, Fla.) 20190515


Studies have investigated CCR5 haplotypes (HHA, HHB, HHC, HHD, HHE, HHF*1, HHF*2, HHG*1, HHG*2), defined by seven 5'UTR single nucleotide polymorphisms (SNPs), CCR2-V64I and CCR5Δ32, in HIV-1 disease. CCR5 cis-regulatory regions were sequenced, CCR2-V64I and CCR5Δ32 genotyped, and compared in HIV-1-infected black South Africans: 71 HIV-1 controllers (23 elite controllers, 37 viraemic controllers (VCs), 11 high viral load long-term non-progressors) and 74 progressors. The HHE haplotype and 3'UTR  ...[more]

Similar Datasets

| S-EPMC4625661 | biostudies-literature
| S-EPMC6053407 | biostudies-literature
| S-EPMC8720782 | biostudies-literature
| S-EPMC3086605 | biostudies-literature
| S-EPMC4326702 | biostudies-literature
| S-EPMC4333678 | biostudies-literature
| S-EPMC8346194 | biostudies-literature
| S-EPMC6466913 | biostudies-literature
| S-EPMC8752124 | biostudies-literature
| S-EPMC4323640 | biostudies-literature