Ontology highlight
ABSTRACT:
SUBMITTER: Koor GW
PROVIDER: S-EPMC6646080 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Koor Gemma W GW Paximadis Maria M Picton Anabela C P ACP Karatas Fidan F Loubser Shayne A SA He Weijing W Ahuja Sunil K SK Chaisson Richard E RE Martinson Neil N Ebrahim Osman O Tiemessen Caroline T CT
Clinical immunology (Orlando, Fla.) 20190515
Studies have investigated CCR5 haplotypes (HHA, HHB, HHC, HHD, HHE, HHF*1, HHF*2, HHG*1, HHG*2), defined by seven 5'UTR single nucleotide polymorphisms (SNPs), CCR2-V64I and CCR5Δ32, in HIV-1 disease. CCR5 cis-regulatory regions were sequenced, CCR2-V64I and CCR5Δ32 genotyped, and compared in HIV-1-infected black South Africans: 71 HIV-1 controllers (23 elite controllers, 37 viraemic controllers (VCs), 11 high viral load long-term non-progressors) and 74 progressors. The HHE haplotype and 3'UTR ...[more]