A statistical method for joint estimation of cis-eQTLs and parent-of-origin effects under family trio design.

ABSTRACT: RNA sequencing allows one to study allelic imbalance of gene expression, which may be due to genetic factors or genomic imprinting (i.e., higher expression of maternal or paternal allele). It is desirable to model both genetic and parent-of-origin effects simultaneously to avoid confounding and to improve the power to detect either effect. In studies of genetically tractable model organisms, separation of genetic and parent-of-origin effects can be achieved by studying reciprocal cross of two inbred strains. In contrast, this task is much more challenging in outbred populations such as humans. To address this challenge, we propose a new framework to combine experimental strategies and novel statistical methods. Specifically, we propose to study genetic and imprinting effects in family trio

SUBMITTER: Zhabotynsky V 

PROVIDER: S-EPMC6646089 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature