Functional spectroscopic imaging reveals specificity of glutamate response in mouse brain to peripheral sensory stimulation.

ABSTRACT: Non-invasive investigation of physiological changes and metabolic events associated with brain activity in mice constitutes a major challenge. Conventionally, fMRI assesses neuronal activity by evaluating activity-evoked local changes in blood oxygenation levels (BOLD). In isoflurane-anaethetized mice, however, we found that BOLD signal changes during paw stimulation appear to be dominated by arousal responses even when using innocuous stimuli. Widespread responses involving both hemispheres have been observed in response to unilateral stimulation. MRS allows probing metabolic changes associated with neuronal activation and provides a complementary readout to BOLD fMRI for investigating brain activity. In this study we evaluated the sensitivity of a free induction decay (FID) based spectro

SUBMITTER: Seuwen A 

PROVIDER: S-EPMC6646328 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature