ERβ promotes Aβ degradation via the modulation of autophagy.

ABSTRACT: Alzheimer's Disease (AD) is the most common neurodegenerative disorder in the elderly. Beta-amyloid (Aβ) peptide accumulation is considered as a primary cause of AD pathogenesis, with defective autophagy in patients' brains. Enhanced autophagic activity has been reported to promote Aβ clearance in vitro and in vivo models. Meanwhile, there is growing evidence that estrogen receptor β (ERβ) is a viable therapeutic target that can ameliorate the pathological features associated with AD. Very little is known about the detailed molecular mechanisms underlying the relationship between ERβ, autophagy, and Aβ degradation in AD. This study aims to uncover whether ERβ participates in autophagy and promotes extracellular Aβ_1-42 degradation through the autophagy-lysosome system. Here we fi

SUBMITTER: Wei Y 

PROVIDER: S-EPMC6646346 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature