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Innovative Tools for Mechanobiology: Unraveling Outside-In and Inside-Out Mechanotransduction.

ABSTRACT: Cells and tissues can sense and react to the modifications of the physico-chemical properties of the extracellular environment (ECM) through integrin-based adhesion sites and adapt their physiological response in a process called mechanotransduction. Due to their critical localization at the cell-ECM interface, transmembrane integrins are mediators of bidirectional signaling, playing a key role in "outside-in" and "inside-out" signal transduction. After presenting the basic conceptual fundamentals related to cell mechanobiology, we review the current state-of-the-art technologies that facilitate the understanding of mechanotransduction signaling pathways. Finally, we highlight innovative technological developments that can help to advance our understanding of the mechanisms underlying nuclear mechanotransduction.

SUBMITTER: Mohammed D

PROVIDER: S-EPMC6646473 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Innovative Tools for Mechanobiology: Unraveling Outside-In and Inside-Out Mechanotransduction.

Mohammed Danahe D Versaevel Marie M Bruyère Céline C Alaimo Laura L Luciano Marine M Vercruysse Eléonore E Procès Anthony A Gabriele Sylvain S

Frontiers in bioengineering and biotechnology 20190716

Cells and tissues can sense and react to the modifications of the physico-chemical properties of the extracellular environment (ECM) through integrin-based adhesion sites and adapt their physiological response in a process called mechanotransduction. Due to their critical localization at the cell-ECM interface, transmembrane integrins are mediators of bidirectional signaling, playing a key role in "outside-in" and "inside-out" signal transduction. After presenting the basic conceptual fundamenta ...[more]

PMID: 31380357

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