Biological Assessment of a ¹⁸F-Labeled Sulforhodamine 101 in a Mouse Model of Alzheimer's Disease as a Potential Astrocytosis Marker.

ABSTRACT: Neurodegenerative diseases have mainly been associated with neuronal death. Recent investigations have shown that astroglia may modulate neuroinflammation in the early and late stages of the disease. [¹¹C]Deuterodeprenyl ([¹¹C]DED) is a tracer that has been used for reactive astrocyte detection in Alzheimer's disease, Creutzfeldt-Jakob disease and amyotrophic lateral sclerosis, among others, with some limitations. To develop a new radiotracer for detecting astrocytosis and overcoming associated difficulties, we recently reported the synthesis of a sulfonamide derivative of Sulforhodamine 101 (SR101), labeled with ¹⁸F, namely SR101 N-(3-[¹⁸F]Fluoropropyl) sulfonamide ([¹⁸F]2B-SRF101). The red fluorescent dye SR101 has been used a

SUBMITTER: Kreimerman I 

PROVIDER: S-EPMC6646682 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature