Generation of a Functioning and Self-Renewing Diaphragmatic Muscle Construct.

ABSTRACT: Surgical repair of large muscular defects requires the use of autologous graft transfer or prosthetic material. Naturally derived matrices are biocompatible materials obtained by tissue decellularization and are commonly used in clinical practice. Despite promising applications described in the literature, the use of acellular matrices to repair large defects has been only partially successful, highlighting the need for more efficient constructs. Scaffold recellularization by means of tissue engineering may improve not only the structure of the matrix, but also its ability to functionally interact with the host. The development of such a complex construct is challenging, due to the complexity of the native organ architecture and the difficulties in recreating the cellular niche with both p

SUBMITTER: Trevisan C 

PROVIDER: S-EPMC6646700 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature