Methylphenidate and the risk of psychosis in adolescents and young adults: a population-based cohort study.

ABSTRACT:

Background

There is a clinical concern that prescribing methylphenidate, the most common pharmacological treatment for attention-deficit hyperactivity disorder (ADHD), might increase the risk of psychotic events, particularly in young people with a history of psychosis. We aimed to determine whether the risk of psychotic events increases immediately after initiation of methylphenidate treatment or, in the longer term, 1 year after treatment initiation in adolescents and young adults with and without a previously diagnosed psychotic disorder.

Methods

In this cohort study, we used population-based observational data from the Swedish Prescribed Drug Register, the National Patient Register, and the Total Population Register, three population-based registers containing data on al

SUBMITTER: Hollis C 

PROVIDER: S-EPMC6646837 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature