Design and Synthesis of Imidazole and Triazole Pyrazoles as <i>Mycobacterium Tuberculosis</i> CYP121A1 Inhibitors.

ABSTRACT: The emergence of untreatable drug-resistant strains of Mycobacterium tuberculosis is a major public health problem worldwide, and the identification of new efficient treatments is urgently needed. Mycobacterium tuberculosis cytochrome P450 CYP121A1 is a promising drug target for the treatment of tuberculosis owing to its essential role in mycobacterial growth. Using a rational approach, which includes molecular modelling studies, three series of azole pyrazole derivatives were designed through two synthetic pathways. The synthesized compounds were biologically evaluated for their inhibitory activity towards M. tuberculosis and their protein binding affinity (K _D). Series 3 biarylpyrazole imidazole derivatives were the most effective with the isobutyl

SUBMITTER: Kishk SM 

PROVIDER: S-EPMC6646865 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature