Supramolecular Tuning of H₂S Release from Aromatic Peptide Amphiphile Gels: Effect of Core Unit Substituents.

ABSTRACT: H₂S is a gasotransmitter with several physiological roles, but its reactivity and short half-life in biological media make its controlled delivery difficult. For biological applications of the gas, hydrogels have the potential to deliver H₂S with several advantages over other donor systems, including localized delivery, controlled release rates, biodegradation, and variable mechanical properties. In this study, we designed and evaluated peptide-based H₂S-releasing hydrogels with controllable H₂S delivery. The hydrogels were prepared from short, self-assembling aromatic peptide amphiphiles (APAs), functionalized on their N-terminus with S-aroylthiooximes (SATOs), which release H₂S in response to a thiol trigger. The APAs were studied bo

SUBMITTER: Qian Y 

PROVIDER: S-EPMC6646883 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature