Adverse pregnancy and perinatal outcome in patients with recurrent pregnancy loss: Multiple imputation analyses with propensity score adjustment applied to a large-scale birth cohort of the Japan Environment and Children's Study.

ABSTRACT:

Problem

Several studies have reported the increased risk of preterm birth, premature rupture of membranes, and low birth weight in patients with recurrent pregnancy loss (RPL). There have been a limited number of large population-based studies examining adverse pregnancy and perinatal outcome after RPL. Multiple-imputed analyses (MIA) adjusting for biases due to missing data is also lacking.

Method of study

A nationwide birth cohort study known as the "Japan Environment and Children's Study (JECS)" was conducted by the Ministry of the Environment. The subjects consisted of 104 102 registered children (including fetuses or embryos).

Results

No increased risk of a congenital anomaly, aneuploidy, neonatal asphyxia, or a small for date infant was observed among the childr

SUBMITTER: Sugiura-Ogasawara M 

PROVIDER: S-EPMC6646903 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature