Integrated Remodeling of Gut-Liver Metabolism Induced by Moderate Protein Restriction Contributes to Improvement of Insulin Sensitivity.

ABSTRACT:

Scope

Protein restriction (PR) is beneficial for relieving metabolic disorders and aging-related diseases. However, extreme PR could result in malnutrition due to severe deficiency of essential amino acids. Therefore, the effect of moderate PR on insulin sensitivity is investigated.

Methods and results

The growing and adult pigs are subjected to moderate PR by 15-30%. Plasma insulin concentration and insulin resistance index HOMA-IR are significantly decreased upon moderate PR. Furthermore, IRS1/PI3K/AKT pathway in the basal state is enhanced in both liver and skeletal muscle. The adapted metabolism in the liver upon moderate PR is in support of improving insulin sensitivity. The liver shares a coordinated metabolic adaption in terms of energy metabolism and amino acid metab

SUBMITTER: Zhang X 

PROVIDER: S-EPMC6646914 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature