Identification of a TLR2 Inhibiting Wheat Hydrolysate.

ABSTRACT:

Scope

Wheat hydrolysates are used in medical nutrition to provide undernourished patients a readily digestible protein source, for instance to recover from chemotherapy-induced intestinal mucosal inflammation. Since many hydrolysates of different sources can modulate the immune system, likely via Toll-like receptors (TLRs), it is hypothesized that also wheat hydrolysates might interact with TLR signaling, which could be a way to prevent intestinal inflammation and damage.

Methods and results

The capacity of three wheat hydrolysates to modulate immunity by interfering with TLR signaling is determined. All wheat hydrolysates have TLR modulating effects but only one has strong TLR2 inhibiting effects, attenuating both TLR2/1 and TLR2/6 signaling in a reporter cell system. This

SUBMITTER: Kiewiet MBG 

PROVIDER: S-EPMC6646915 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature