Lifetime Risk and Heritability of Amyotrophic Lateral Sclerosis.

ABSTRACT:

Importance

Heritability describes the proportion of variance in the risk of developing a condition that is explained by genetic factors. Although amyotrophic lateral sclerosis (ALS) is known to have a complex genetic origin, disease heritability remains unclear.

Objectives

To determine the extent of ALS heritability and assess the association of sex with disease transmission.

Design, setting, and participants

A prospective population-based parent-offspring heritability study was conducted from January 1, 2008, to December 31, 2017 to assess ALS heritability, and was the first study to assess heritability in the context of known gene mutations of large effect. A total of 1123 incident cases of ALS, diagnosed according to the El Escorial criteria and recorded on the Iri

SUBMITTER: Ryan M 

PROVIDER: S-EPMC6646974 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature