Association of Genetic and Environmental Factors With Autism in a 5-Country Cohort.

ABSTRACT:

Importance

The origins and development of autism spectrum disorder (ASD) remain unresolved. No individual-level study has provided estimates of additive genetic, maternal, and environmental effects in ASD across several countries.

Objective

To estimate the additive genetic, maternal, and environmental effects in ASD.

Design, setting, and participants

Population-based, multinational cohort study including full birth cohorts of children from Denmark, Finland, Sweden, Israel, and Western Australia born between January 1, 1998, and December 31, 2011, and followed up to age 16 years. Data were analyzed from September 23, 2016 through February 4, 2018.

Main outcomes and measures

Across 5 countries, models were fitted to estimate variance components describing the tot

SUBMITTER: Bai D 

PROVIDER: S-EPMC6646998 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature