In utero vitamin D deficiency predisposes offspring to long-term adverse adipose tissue effects.

ABSTRACT: The fetal period represents an important window of susceptibility for later obesity and metabolic disease. Maternal vitamin D deficiency (VDD) during pregnancy is a global concern that may have long-lasting consequences on offspring metabolic health. We sought to determine whether a VDD in utero environment affects fetal adipose tissue development and offspring metabolic disease predisposition in adulthood. Furthermore, we sought to explore the extent to which the VDD intrauterine environment interacts with genetic background or postnatal environment to influence metabolic health. Eight-week-old P₀ female C57BL/6J mice were fed either a VDD diet or sufficient diet (VDS) from four weeks before pregnancy (periconception) then bred to male A^vy/a</

SUBMITTER: Belenchia AM 

PROVIDER: S-EPMC6647013 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature