Early in vivo experience with the pediatric continuous-flow total artificial heart.

ABSTRACT:

Background

Heart transplantation in infants and children is an accepted therapy for end-stage heart failure, but donor organ availability is low and always uncertain. Mechanical circulatory support is another standard option, but there is a lack of intracorporeal devices due to size and functional range. The purpose of this study was to evaluate the in vivo performance of our initial prototype of a pediatric continuous-flow total artificial heart (P-CFTAH), comprising a dual pump with one motor and one rotating assembly, supported by a hydrodynamic bearing.

Methods

In acute studies, the P-CFTAH was implanted in 4 lambs (average weight: 28.7 ± 2.3 kg) via a median sternotomy under cardiopulmonary bypass. Pulmonary and systemic pump performance parameters were recorded.

Res

SUBMITTER: Karimov JH 

PROVIDER: S-EPMC6647019 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature