Opioid Analgesic Use and Risk for Invasive Pneumococcal Diseases: A Nested Case-Control Study.

ABSTRACT:

Background

Although certain opioid analgesics have immunosuppressive properties and increase the risk for infections in animals, the clinical effects of prescription opioid use on infection risk among humans are unknown.

Objective

To test the hypothesis that prescription opioid use is an independent risk factor for invasive pneumococcal disease (IPD).

Design

Nested case-control study.

Setting

Tennessee Medicaid database linked to Medicare and Active Bacterial Core surveillance system databases (1995 to 2014).

Patients

1233 case patients with IPD aged 5 years and older matched to 24 399 control participants by diagnosis date, age, and county of residence.

Measurements

Opioid use was measured on the basis of pharmacy prescription fills. Invasive pne

SUBMITTER: Wiese AD 

PROVIDER: S-EPMC6647022 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature