Changes in Visceral and Subcutaneous Fat in Youth With Type 2 Diabetes in the TODAY Study.

ABSTRACT:

Objective

In the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study, metformin plus rosiglitazone (M + R) maintained glycemic control better than metformin alone (M) or metformin plus lifestyle (M + L) in youth with type 2 diabetes (T2D). We hypothesized that changes in visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) would explain the differential treatment effects on glycemia.

Research design and methods

In 626 youth ages 11-17 years with T2D duration <2 years, VAT and SAT were estimated by DXA at baseline and at 6 and 24 months. Changes from baseline were analyzed in linear mixed models.

Results

Baseline mean age was 13.9 years, 66.4% were female, 72.2% were Hispanic/non-Hispanic black, and 20.3% were non-Hispanic white

SUBMITTER: Dhaliwal R 

PROVIDER: S-EPMC6647052 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature