Intravenous-to-oral antibiotic switch therapy: a cross-sectional study in critical care units.

ABSTRACT:

Background

This study aimed to evaluate the oral switch (OS) stewardship intervention in the intensive care unit (ICU).

Methods

This was a retrospective study with a convenience sample in two Brazilian ICUs from different hospitals in patients with sepsis receiving antibiotic therapy. The stewardship intervention included OS in patients diagnosed with sepsis when clinical stability was achieved. The primary outcome was overall mortality. Other variables evaluated were as follows: cost of antimicrobial treatment, daily costs of intensive care, acute kidney injury, and length of stay.

Results

There was no difference in mortality between the OS and non-OS groups (p = 0.06). Length of stay in the ICU (p = 0.029) was shorter and acute kidney injury incidence (p = 0.032) an

SUBMITTER: Gasparetto J 

PROVIDER: S-EPMC6647098 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature