Interobserver reproducibility of tumor uptake quantification with ⁸⁹Zr-immuno-PET: a multicenter analysis.

ABSTRACT:

Purpose

In-vivo quantification of tumor uptake of 89-zirconium (⁸⁹Zr)-labelled monoclonal antibodies (mAbs) with PET provides a potential tool in strategies to optimize tumor targeting and therapeutic efficacy. A specific challenge for ⁸⁹Zr-immuno-PET is low tumor contrast. This is expected to result in interobserver variation in tumor delineation. Therefore, the aim of this study was to determine interobserver reproducibility of tumor uptake measures by tumor delineation on ⁸⁹Zr-immuno-PET scans.

Methods

Data were obtained from previously published clinical studies performed with ⁸⁹Zr-rituximab, ⁸⁹Zr-cetuximab and ⁸⁹Zr-trastuzumab. Tumor lesions on ⁸⁹Zr-immuno-PET were identified as focal uptake ex

SUBMITTER: Jauw YWS 

PROVIDER: S-EPMC6647131 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature