High-flow nasal therapy versus noninvasive ventilation in COPD patients with mild-to-moderate hypercapnic acute respiratory failure: study protocol for a noninferiority randomized clinical trial.

ABSTRACT:

Background

Noninvasive ventilation (NIV) is indicated to treat respiratory acidosis due to exacerbation of chronic obstructive pulmonary disease (COPD). Recent nonrandomized studies also demonstrated some physiological effects of high-flow nasal therapy (HFNT) in COPD patients. We designed a prospective, unblinded, multicenter, randomized controlled trial to assess the noninferiority of HFNT compared to NIV with respect to the reduction of arterial partial pressure of carbon dioxide (PaCO₂) in patients with hypercapnic acute respiratory failure with mild-to-moderate respiratory acidosis.

Methods

We will enroll adult patients with acute hypercapnic respiratory failure, as defined by arterial pH between 7.25 and 7.35 and PaCO₂ ≥ 55 mmHg. Patients will be

SUBMITTER: Cortegiani A 

PROVIDER: S-EPMC6647141 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature