TNF blockade contributes to restore lipid oxidation during exercise in children with juvenile idiopathic arthritis.

ABSTRACT:

Background

Children with juvenile idiopathic arthritis (JIA) have impaired physical abilities. TNF-α plays a crucial role in this pathogenesis, but it is also involved in the use of lipids and muscle health. Objective of this study was to explore substrate oxidation and impact of TNF blockade on energy metabolism in children with JIA as compared to healthy children.

Methods

Fifteen non-TNF-blockaded and 15 TNF-blockaded children with JIA and 15 healthy controls were matched by sex, age, and Tanner stage. Participants completed a submaximal incremental exercise test on ergocycle to determine fat and carbohydrate oxidation rates by indirect calorimetry.

Results

The maximal fat oxidation rate during exercise was lower in JIA children untreated by TNF blockade (134.3 ± 45

SUBMITTER: Rochette E 

PROVIDER: S-EPMC6647146 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature