Lesion detection by [⁸⁹Zr]Zr-DFO-girentuximab and [¹⁸F]FDG-PET/CT in patients with newly diagnosed metastatic renal cell carcinoma.

ABSTRACT:

Purpose

The main objective of this preliminary analysis of the IMaging PAtients for Cancer drug selecTion (IMPACT)-renal cell cancer (RCC) study is to evaluate the lesion detection of baseline contrast-enhanced CT, [⁸⁹Zr]Zr-DFO-girentuximab-PET/CT and [¹⁸F]FDG-PET/CT in detecting ccRCC lesions in patients with a good or intermediate prognosis metastatic clear cell renal cell carcinoma (mccRCC) according to the International Metastatic Database Consortium (IMDC) risk model.

Methods

Between February 2015 and March 2018, 42 newly diagnosed mccRCC patients with good or intermediate prognosis, eligible for watchful waiting, were included. Patients underwent CT, [⁸⁹Zr]Zr-DFO-girentuximab-PET/CT and [¹⁸F]FDG-PET/CT at baseline. Scans were

SUBMITTER: Verhoeff SR 

PROVIDER: S-EPMC6647180 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature