Prediction of regulatory long intergenic non-coding RNAs acting in trans through base-pairing interactions.

ABSTRACT:

Background

Long intergenic non-coding RNAs (lincRNAs) can act as regulators of expression of protein-coding genes. Trans-natural antisense transcripts (trans-NATs) are a type of lincRNAs that contain sequence complementary to mRNA from other loci. The regulatory potential of trans-NATs has been poorly studied in eukaryotes and no example of trans-NATs regulating gene expression in plants are reported. The goal of this study was to identify lincRNAs, and particularly trans-NATs, in Arabidopsis thaliana that have a potential to regulate expression of target genes in trans at the transcriptional or translational level.

Results

We identified 1001 lincRNAs using an RNAseq dataset from total polyA⁺ and polysome-associated RNA of seedlings grown under high and low phosph

SUBMITTER: Deforges J 

PROVIDER: S-EPMC6647327 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature