ESCRT Proteins Control the Dendritic Morphology of Developing and Mature Hippocampal Neurons.

ABSTRACT: The proper shape of dendritic arbors of different types of neurons determines their proper communication within neuronal networks. The shape of dendritic arbors is acquired during a complex and multistep process called dendritogenesis. In most cases, once proper morphology is achieved, it remains stable throughout the lifespan, with the exception of rare events during which dendrites are abruptly pruned. The endosomal sorting complex required for transport (ESCRT) is multisubunit machinery that is involved in various cellular processes when membrane scission is needed. ESCRT subcomplexes regulate dendrite pruning in Drosophila neurons. However, the contribution of ESCRT components to the dendritogenesis of mammalian neurons and control of dendrite stability remains poorly defined. In the p

SUBMITTER: Firkowska M 

PROVIDER: S-EPMC6647414 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature