Item Response Model Adaptation for Analyzing Data from Different Versions of Parkinson's Disease Rating Scales.

ABSTRACT:

Purpose

The aim of this work was to allow combination of information from recent and historical trials in Parkinson's Disease (PD) by developing bridging methodology between two versions of the clinical endpoint.

Methods

A previously developed Item Response Model (IRM), that described longitudinal changes in Movement Disorder Society (MDS) sponsored revision of Unified Parkinson's Disease Rating Scale (UPDRS) [MDS-UPDRS] data from the De Novo PD cohort in Parkinson's Progression Markers Initiative, was first adapted to describe baseline UPDRS data from two clinical trials, one in subjects with early PD and another in subjects with advanced PD. Assuming similar IRM structure, items of the UPDRS version were mapped to those in the MDS-UPDRS version. Subsequently, the longitudi

SUBMITTER: Gottipati G 

PROVIDER: S-EPMC6647468 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature