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Distinct phenotype of CD4⁺ T cells driving celiac disease identified in multiple autoimmune conditions.

ABSTRACT: Combining HLA-DQ-gluten tetramers with mass cytometry and RNA sequencing analysis, we find that gluten-specific CD4⁺ T cells in the blood and intestines of patients with celiac disease display a surprisingly rare phenotype. Cells with this phenotype are also elevated in patients with systemic sclerosis and systemic lupus erythematosus, suggesting a way to characterize CD4⁺ T cells specific for disease-driving antigens in multiple autoimmune conditions.

SUBMITTER: Christophersen A

PROVIDER: S-EPMC6647859 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Distinct phenotype of CD4⁺ T cells driving celiac disease identified in multiple autoimmune conditions.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Distinct phenotype of CD4+ T cells driving celiac disease identified in multiple autoimmune conditions.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Distinct phenotype of CD4⁺ T cells driving celiac disease identified in multiple autoimmune conditions.