ABC Transporter Genes Show Upregulated Expression in Drug-Resistant Clinical Isolates of <i>Candida auris</i>: A Genome-Wide Characterization of ATP-Binding Cassette (ABC) Transporter Genes.

ABSTRACT: ATP-binding cassette (ABC) superfamily members have a key role as nutrient importers and exporters in bacteria. However, their role as drug exporters in eukaryotes brought this superfamily member to even greater prominence. The capacity of ABC transporters to efflux a broad spectrum of xenobiotics represents one of the major mechanisms of clinical multidrug resistance in pathogenic fungi including Candida species. Candida auris, a newly emerged multidrug-resistant fungal pathogen of humans, has been responsible for multiple outbreaks of drug-resistant infections in hospitals around the globe. Our study has analyzed the entire complement of ABC superfamily transporters to assess whether these play a major role in drug resistance mechanisms of C. auris. Our bioinformatic

SUBMITTER: Wasi M 

PROVIDER: S-EPMC6647914 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature