Quinazolinone Synthesis through Base-Promoted S_NAr Reaction of ortho-Fluorobenzamides with Amides Followed by Cyclization.

ABSTRACT: A transition-metal-free synthesis of quinazolin-4-ones by Cs₂CO₃-promoted S_NAr reaction of ortho-fluorobenzamides with amides followed by cyclization in dimethyl sulfoxide has been developed. The present procedure can provide efficient synthetic methods for the formation of both 2-substituted and 2,3-disubstituted quinazolin-4-one rings depending on the use of easily available starting materials and an efficient, one-pot protocol for the synthesis of the marketed drug product of methaqualone.

SUBMITTER: Iqbal MA 

PROVIDER: S-EPMC6647956 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature