Assembly of Multicomponent Nano-Bioconjugates Composed of Mesoporous Silica Nanoparticles, Proteins, and Gold Nanoparticles.

ABSTRACT: The purpose of this work was the assembly of multicomponent nano-bioconjugates based on mesoporous silica nanoparticles (MSNs), proteins (bovine serum albumin, BSA, or lysozyme, LYZ), and gold nanoparticles (GNPs). These nano-bioconjugates may find applications in nanomedicine as theranostic devices. Indeed, MSNs can act as drug carriers, proteins stabilize MSNs within the bloodstream, or may have therapeutic or targeting functions. Finally, GNPs can either be used as contrast agents for imaging or for photothermal therapy. Here, amino-functionalized MSNs (MSN-NH₂) were synthesized and characterized through various techniques (small angle X-rays scattering TEM, N₂ adsorption/desorption isotherms, and thermogravimetric analysis (TGA)). BSA or lysozyme were then grafted

SUBMITTER: Delpiano GR 

PROVIDER: S-EPMC6647957 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature