Dual Stimuli-Responsive Block Copolymers for Controlled Release Triggered by Upconversion Luminescence or Temperature Variation.

ABSTRACT: An amphiphilic block copolymer (BCP) which contains both photoresponsive and thermoresponsive blocks was synthesized by the atom transfer radical polymerization approach. Meanwhile, a new core/shell type of the upconversion nanoparticle (UCNP) LiYF₄:Yb³⁺ _0.25,Tm³⁺ _0.01@LiYF₄:Yb³⁺ _0.2 was successfully synthesized. By encapsulating UCNPs inside the micelles of the BCP and incorporating Nile red (NR) into the UCNP@BCP hybrid nanoparticles as a model drug, controlled release of the drug by the dual-stimuli BCP could be studied. After exposing the UCNP-loaded micellar solution to near-infrared (NIR) light, it was found that the UV light pumped from UCNPs could disrupt the polymer micelles and the fluorescenc

SUBMITTER: Chung YC 

PROVIDER: S-EPMC6648012 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature