Total Synthesis of Marine Natural Products Serinolamide A and Columbamide D.

ABSTRACT: In this report, an expeditious synthesis of two new biologically active marine natural products serinolamide A and columbamide D is documented. This convergent approach involves the key steps such as hydrolytic kinetic resolution, cross metathesis, Grignard reaction, Johnson-Claisen rearrangement, Mitsunobu, and so forth. Both of the target molecules were obtained from a common precursor (R)-7 with high enantioselectivity, less synthetic steps, and in good overall yields (serinolamide A 66% and columbamide D 62%).

SUBMITTER: Ghotekar GS 

PROVIDER: S-EPMC6648212 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature