Rheological and Mechanical Investigation into the Effect of Different Molecular Weight Poly(ethylene glycol)s on Polycaprolactone-Ciprofloxacin Filaments.

ABSTRACT: Fused deposition fabrication (FDF) three-dimensional printing is a potentially transformative technology for fabricating pharmaceuticals. The state-of-the-art technology is still in its infancy and requires a concerted effort to realize its potential. One aspect includes the processing parameters of FDF and the effect of formulation thereto, which, to date, have not been thoroughly investigated. To progress understanding, the effect of different molecular weight poly(ethylene glycol)s (PEG) on polycaprolactone (PCL) loaded with ciprofloxacin (CIP) was investigated. A rheometer was used, and adapted accordingly, to analyze three processing aspects pertaining to FDF: viscosity, solidification, and adhesion. The results revealed that both CIP and PEG affected all three processing parameters.

SUBMITTER: Elbadawi M 

PROVIDER: S-EPMC6648292 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature