Synthesis of Stimuli-Responsive Heterofunctional Dendrimer by Passerini Multicomponent Reaction.

ABSTRACT: We report the synthesis of a structurally diverse amphiphilic dendrimer with oxidation and ultraviolet light-sensitive groups incorporated in the dendrimer interior. Convergent synthesis is utilized by reacting branched repeating units with a nonbranched functional molecule by two synthetic strategies, Passerini multicomponent reaction and azide-alkyne cycloaddition reaction. The periphery of dendrimer was functionalized by methoxy poly(ethylene glycol) to obtain a dendrimer with a hydrophobic core and hydrophilic peripheral chains. The G2-PEG dendrimer characterized by NMR, GPC, and MALDI-TOF MS for structural integrity and oxidation- and photo-triggered degradations of the G2-PEG dendrimer was investigated. The self-assembled morphology of the dendrimer in the presence of organic dye was

SUBMITTER: Patil NG 

PROVIDER: S-EPMC6648294 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature