Physicochemical Properties Govern the Activity of Potent Antiviral Flavones.

ABSTRACT: Ladanein (i.e., 5,6,7-trihydroxylated flavone) was demonstrated to act as a powerful virucidal agent toward a broad range of enveloped virus particles. Fe(III) coordination and pH are indeed among the key parameters that might favor both bioactivation of the flavone and consequent host cell entry inhibition. In this present work, the impact of fluorinated groups on the physicochemical and antiviral properties of the flavone was investigated, thus allowing a deeper understanding of the antiviral mode of action. The improved synthesis of ladanein allowed accessing a broad range of analogues, some of them being significantly more active than the former ladanein lead compound. We first determined the acido-basic properties of this homogenous series of compounds and then investigated their elec

SUBMITTER: Martin-Benlloch X 

PROVIDER: S-EPMC6648324 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature